Anna Måsbäck

Anna_MOvarian tumors and the use of immunohistochemical staining
in clinical practice.

The ovary harbour many different tumor types, and metastatic disease is common. The use of immunohistochemical stainings, and other techniques, is neccessary when diagnosis matters for choice of treatment. Since the survival of ovarian carcinoma only has been slightly improved during the last decades it is also of importance to subtype ovarian tumours as exactly as possible to facilitate the identification of subgroups and their proneness to treatment response. Different analyses and their interpretation will be exposed.

CV

Specialist in Surgical Pathology 2000. PhD 2002, Thesis: Malignant Melanoma in Southern Sweden; Histopathology, Prognosis and Etiology. Reference pathologist for gynaecopathology in Southern Swedish region since 2002. Member of the KVAST (Quality and Standardization)-group for gynaecopathology within the Swedish Society of Pathologists since 2008. Member of the national educating group on Gynecological pathology for residents since 2012. Member of Regional and National Guideline groups for: Ovarian carcinoma, Endometrial carcinoma, Trophoblastic tumors, Cervical carcinoma and Vulvar carcinoma.

Selected references:

Jönsson JM, Skovbjerg Arildsen N, Malander S, Måsbäck A, Hartman L, Nilbert M, Hedenfalk I. Sex Steroid Hormone Receptor Expression Affects Ovarian Cancer Survival. Transl Oncol. 2015 Oct;8(5):424-33. doi: 10.1016/j.tranon.2015.09.002. PubMed PMID: 26500033; PubMed Central PMCID: PMC4631098.

Green RW, Engblom S, Baldetorp B, Hartman L, Måsbäck A, Bjurberg M. Cell proliferation, measured as flow cytometric S-phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population-based study. Acta Obstet Gynecol Scand. 2015 Oct;94(10):1064-73. doi: 10.1111/aogs.12704. PubMed PMID: 26123703.

Jönsson JM, Johansson I, Dominguez-Valentin M, Kimbung S, Jönsson M, Bonde JH, Kannisto P, Måsbäck A, Malander S, Nilbert M, Hedenfalk I. Molecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes. PLoS One. 2014 Sep 16;9(9):e107643. doi: 10.1371/journal.pone.0107643. eCollection 2014. PubMed PMID: 25226589; PubMed Central PMCID: PMC4166462.

Jönsson JM, Bartuma K, Dominguez-Valentin M, Harbst K, Ketabi Z, Malander S, Jönsson M, Carneiro A, Måsbäck A, Jönsson G, Nilbert M. Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome. Fam Cancer. 2014 May 22. [Epub ahead of print] PubMed PMID: 24848881.

Köbel M, Bak J, Bertelsen BI, Carpen O, Grove A, Hansen ES, Levin Jakobsen AM, Lidang M, Måsbäck A, Tolf A, Gilks CB, Carlson JW. Ovarian carcinoma histotype determination is highly reproducible, and is improved through the use of immunohistochemistry. Histopathology. 2014 Jun;64(7):1004-13. doi: 10.1111/his.12349. Epub 2014 Mar 7. PubMed PMID: 24329781.

Epstein E, Testa A, Gaurilcikas A, Di Legge A, Ameye L, Atstupenaite V, Valentini AL, Gui B, Wallengren NO, Pudaric S, Cizauskas A, Måsbäck A, Zannoni GF, Kannisto P, Zikan M, Pinkavova I, Burgetova A, Dundr P, Nemejcova K, Cibula D, Fischerova D. Early-stage cervical cancer: tumor delineation by magnetic resonance imaging and ultrasound – a European multicenter trial. Gynecol Oncol. 2013 Mar;128(3):449-53. doi: 10.1016/j.ygyno.2012.09.025. Epub 2012 Sep 28.PubMed PMID: 23022593