Automation has impregnated the process of sample processing and analysis in many areas of Pathology and Laboratory Medicine. Indeed, clinical biochemistry and molecular virology are almost fully automated. However, tissue pathology is still a relatively slow and laborious process, represented by a large list of semi-independent tasks. This lecture aims to explore how digital pathology can help this pathway by a) assisting the morphological analysis of samples; b) automated scoring of IHC and ISH; and c) annotating samples ahead of molecular testing. This will be explained using examples of tissue testing associated to personalized medicine and cancer immunotherapy.
Digital pathology and image analysis in tissue biomarker research. Hamilton PW, Bankhead P, Wang Y, Hutchinson R, Kieran D, McArt DG, James J, Salto-Tellez M. Methods. 2014 Nov;70(1):59-73.
Digital slide viewing for primary reporting in gastrointestinal pathology: a validation study. Loughrey MB, Kelly PJ, Houghton OP, Coleman HG, Houghton JP, Carson A, Salto-Tellez M, Hamilton PW. Virchows Arch. 2015 Aug;467(2):137-44.
Automated tumor analysis for molecular profiling in lung cancer. Hamilton PW, Wang Y, Boyd C, James JA, Loughrey MB, Hougton JP, Boyle DP, Kelly P, Maxwell P, McCleary D, Diamond J, McArt DG, Tunstall J, Bankhead P, Salto-Tellez M. Oncotarget. 2015 Sep 29;6(29):27938-52.
Manuel Salto-Tellez, Chair of Molecular Pathology, Queen’s University Belfast and Clinical Director, Molecular Diagnostics, Belfast Trust, received his MD in 1991 in Oviedo (Spain), with yearly stints in Aachen (Germany) and Leiden (The Netherlands). He became Fellow of the Royal College of Pathologists of GB and Ireland in 1998 (FRCPath), and Fellow of the Royal College of Physicians of Ireland in 2013 (FRCPI). He took a molecular pathology Fellowship in the University of Pennsylvania (2001), and worked in Singapore for over a decade. Manuel is a surgical pathologist and a molecular diagnostician, and his diagnostic and research activity over the last 15 years has been centered in marrying phenotype and genotype in cancer pathology. He is author of more than 230 peer reviewed manuscripts (H factor 50) and holds more than £2M in active grant funding. He leads the Northern Ireland Molecular Pathology Laboratory, a unique integrated model for pathology diagnostics and research.